Michael Geusz

Dr. Michael E. Geusz

Ph. D., Vanderbilt University

Office:     414 Life Sciences Building
Phone:   1-419-372-2433
Email:     mgeusz@bgsu.edu


The role of circadian rhythms in adult neurogenesis, cancer stem cells, and behavior



Research Interests:

The primary interest of the laboratory is the organization of the circadian timing system of mice as a model for studying how circadian rhythms in behavior and physiology affect cancer and other diseases. The interactions between the circadian clocks of the nervous system that generate near 24-hour rhythms and the tissues of several target organs are being examined by imaging rhythms in gene expression of whole mice and tissue explant cultures. These cycles are recorded using bioluminescent transgenic mice containing the firefly luciferase gene controlled by immediate-early gene promoters of mPer1, c-fos, and the major immediate-early gene of the human cytomegalovirus. Long-term imaging identified coupled circadian rhythms within the pancreas and cornea and others in midbrain nuclei controlling feeding behavior. These gene expression assays in live cells are combined with pharmacology, histology, neural recordings, and behavioral monitoring to identify the signaling mechanisms acting between the circadian clocks of the nervous system and the body.

Selected Publications:

Adema CM, Hillier LW, Jones CS, Loker ES, Knight M, Minx P, Oliveira G, Raghavan N, Shedlock A, do Amaral LR, Arican-Goktas HD, Assis JG, Baba EH, Baron OL, Bayne CJ, Bickham-Wright U, Biggar KK, Blouin M, Bonning BC, Botka C, Bridger JM, Buckley KM, Buddenborg SK, Lima Caldeira R, Carleton J, Carvalho OS, Castillo MG, Chalmers IW, Christensens M, Clifton S, Cosseau C, Coustau C, Cripps RM, Cuesta-Astroz Y, Cummins SF, Di Stephano L, Dinguirard N, Duval D, Emrich S, Feschotte C, Feyereisen R, FitzGerald P, Fronick C, Fulton L, Galinier R, Gava SG, Geusz M, Geyer KK, Giraldo-Calderón GI, de Souza Gomes M, Gordy MA, Gourbal B, Grunau C, Hanington PC, Hoffmann KF, Hughes D, Humphries J, Jackson DJ, Jannotti-Passos LK, de Jesus Jeremias W, Jobling S, Kamel B, Kapusta A, Kaur S, Koene JM, Kohn AB, Lawson D, Lawton SP, Liang D, Limpanont Y, Liu S, Lockyer AE, Lovato TL, Ludolf F, Magrini V, McManus DP, Medina M, Misra M, Mitta G, Mkoji GM, Montague MJ, Montelongo C, Moroz LL, Munoz-Torres MC, Niazi U, Noble LR, Oliveira FS, Pais FS, Papenfuss AT, Peace R, Pena JJ, Pila EA, Quelais T, Raney BJ, Rast JP, Rollinson D, Rosse IC, Rotgans B, Routledge EJ, Ryan KM, Scholte LLS, Storey KB, Swain M, Tennessen JA, Tomlinson C, Trujillo DL, Volpi EV, Walker AJ, Wang T, Wannaporn I, Warren WC, Wu XJ, Yoshino TP, Yusuf M, Zhang SM, Zhao M, Wilson RK (2017) Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications. May 16; 8: 15451. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440852/ doi: 10.1038/ncomms15451. 

Sarma**, A., Sharma**, V.P., Sarkar, A.B., Sekar, M.C., Samuel*, K., and Geusz, M.E. (2016) The circadian clock modulates anti-cancer properties of curcumin. BMC Cancer 16(1):759. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041585/

Sarma**, A., Sharma**, V.P. and Geusz, M.E. (2016) Circadian rhythms in doxorubicin nuclear uptake and clock control of C6 glioma cells. Journal of Cancer Therapy, 7, 558-572. doi: 10.4236/jct.2016.78059. http://file.scirp.org/pdf/JCT_2016081015202723.pdfMalik**, A., Kondratov, R.V, Jamasbi, R.J., and Geusz, M.E. (2015) Circadian clock genes are essential for normal adult neurogenesis, differentiation, and fate determination. PLoS ONE 10: e0139655. http://www.ncbi.nlm.nih.gov/pubmed/?term=PMC4595423

Malik**, A., Jamasbi, R.J., Kondratov, R.V., and Geusz, M.E. (2015) Development of circadian oscillators in neurosphere cultures during adult neurogenesis. PLoS ONE 10: e0122937. http://www.ncbi.nlm.nih.gov/pubmed/?term=PMC4380296

Geusz, M.E., Sharma**, V.P., Sarma**, A., Malik**, A. (2015) Evaluating circadian oscillators in cancer stem cells. Journal of Evolving Stem Cell Research 1:1. http://openaccesspub.org/journals/jesr/view-article.php?art_id=173&jid=29

Sharma**, V.P., Anderson*, N., and Geusz, M.E. (2014) Circadian properties of cancer stem cells in glioma cell cultures and tumorspheres. Cancer Letters 345: 65-74.