Our research activities are mainly in the areas of protein biochemistry, peptide/protein chemistry, bioanalytical chemistry, chemical biology, and bioengineering. Our research aim is to develop next-generation platform for disease diagnostics and therapy. To realize this aim, we are interested in playing with Nature's building blocks, peptide, protein, DNA and RNA.
Topics of interest:
Fluorescent hairpins, peptide/protein chemistry, aptamer, antibody delivery, antibody mimics
Tan, X.; Bruchez, M.P.; Armitage, B.A. "Efficient Cytoplasmic Delivery of Antisense Probes Assisted by Cyclized‐Peptide‐Mediated Photoinduced Endosomal Escape," ChemBioChem, 2019, 20 (5), 727-733.
Tan, X.; Yang, R.; Liu, C. "Facilitating Subtiligase-Catalyzed Peptide Ligation Reactions by Using Peptide Thioester Substrates," Org. Lett., 2018, 20 (21), 6691-6694.
Tan, X.; Bruchez, M.P.; Armitage, B.A. "Closing the Loop: Constraining TAT Peptide by γPNA Hairpin for Enhanced Cellular Delivery of Biomolecules," Bioconjug., Chem., 2018, 29 (9), 2892-2898.
Tan, X.; Constantin, T.P.; Sloane, K.L.; Waggoner, A.S.; Bruchez, M.P.; Armitage, B.A. "Fluoromodules Consisting of a Promiscuous RNA Aptamer and Red or Blue Fluorogenic Cyanine Dyes: Selection, Characterization, and Bioimaging," J. Am. Chem. Soc., 2018, 139 (26), 9001-9009.
Tan, X.; Armitage, B.A.; Bruchez, M.P. "Label-free Molecular Beacons for Biomolecular Detection," Anal. Chem., 2014, 86 (21), 10864–10869.
Tan, X.; Chen, T.; Xiong, X.; Mao, Y.; Zhu, G.; Yasun, E.; Li, C.; Zhu, Z.; Tan, W. " Semi-quantification of ATP in Live Cells using Nonspecific Desorption of DNA from Graphene Oxide as the Internal Reference," Anal. Chem., 2012, 84 (20), 8622-8627.