R. Marshall Wilson

r. Marshall ImageR. Marshall Wilson, Ph.D.

Research Professor, Chemistry Department
310 Physical Sciences Laboratory Building

Biographical Facts:

Joined the faculty in 2005
Ph.D., Massachusetts Institute of Technology (1965)
B.S., The Pennsylvania State University (1961) 

Research Interests:

Our research interests are directed towards photochemical application of lasers, primarily argon ion lasers, and fall into two broad categories: the laser synthesis of new materials and the development of reagents for the photochemical manipulation of biological systems.  These include:

  • The use of CW laser plasmas to prepare carbon bowls, Bucky Bowls and the study of the properties of these bowl-shaped “aromatic” hydrocarbons.
  • The development of new reagents for the photochemical cross-linking of nucleic acids, primarily RNA, with proteins.
  • The development of new reagents for the photochemical cleavage of nucleic acids, primarily RNA.
  • The development of the aforementioned two techniques to study the interactions between nucleic acids and proteins using mass spectrometry to obtain detailed structural information about the nature of these interactions.

Selected Publications:

“5-Azido-2-aminopyridines, a New Nitrene/Nitreium Ion Photoaffinity Labeling Agent That Exhibits Reversible Intersystem Crossing between Singlet and Triplet Nitrenes”, Maxim S. Panov, Valentyna D. Voskresenska, Mikhail N. Ryasantsev, Alexander N. Tarnovsky* and R. Marshall Wilson*, J. Am. Chem. Soc., submitted.

“Oxidation of Adenosine and Inosine: The Chemistry of 8-Oxo-7,8-dihydropurines, Purine Iminoquinones and Purine Quinones as Observed by Ultrafast Spectroscopy”, Denis I. Nilov, Dmitry Y. Komarov, Maxim S. Panov, Kanykey E. Karabaeva, Andrey S. Mereshchenko, Alexander N. Tarnovsky* and R. Marshall Wilson*, J. Am. Chem. Soc. 2013, 135, 3423-3428. [Link]

“Nitrenium Ions and Related Species in Photoaffinity Labeling” R. Marshall Wilson and Valentyna Voskresenska in “Nitrenes and Nitrenium Ions”, A. Gudmundsdottir and D. Falvey, Editors, Wiley Interscience, 2013, 77-116. [Link]

“Photoaffinity Labeling via Nitrenium Ion Chemistry: Protonation of the Nitrene Derived from 4-Amino-3-nitrophenyl Azide to Afford Reactive Nitrenium Ion Pairs” V. Voskresenska, R. Marshall Wilson, M. Panov, A. N. Tarnovsky, J. A. Krause, S. Vyas, A. H. Winter, C. M. Hadad, C. M. J. Am. Chem. Soc. 2009, 131, 11535-11547. [Link]

"Photoaffinity Labeling with 8-Azidoadenosine and Its Derivatives: The Chemistry of Closed and Open Adenosine Diazaquinodimethanes", Dmitrii Polshakov, Saroj Rai, R. Marshall Wilson, Eric T. Mack, Martin Vogel, Jeanette Krause, Gotard Burdzinski, and Matthew S. Platz Biochemistry, 2005, 44, 11241-112. [Link]