Center for Neuroscience, Mind & Behavior
HOWARD CASEY CROMWELL
JP SCOTT CENTER FOR NEUROSCIENCE, MIND AND BEHAVIOR
HOWARD CASEY CROMWELL PhD
Art work for this shirt was done by Lonnie Rosenberg
I used to think that the
brain was the most wonderful organ in my body.
Then I realized
who was telling me this. (Now I don't know what to think)
Emo Phillips (American Comedian; parenthesis added)
I was a double major in Psychology and Biology at DePauw and took an even number of classes from both departments. My favorite psychology class was Human Relations taught by Professor Felix E.Goodson. My favorite biology class was Animal Behavior taught by Professor Mike Johnson (my undergraduate mentor). My senior thesis project was an investigation on the effects of alcohol ingestion on passive avoidance learning in two different mice strains (Balb/c & C57s; unpublished).
This photo was published in 'The DePauw' newspaper during my collegiate career.
Graduate studies were completed in the laboratory of Dr. Kent C. Berridge in the Biopsychology Program at UM. Based on his earlier work that large lesions of the basal ganglia altered action sequencing in both taste and grooming, we started to examine the effects of small lesions to different portions of the basal ganglia, focusing on the dorsal and ventral striatum and the pallidal regions. We found distinct differences following lesions to the different subregions. My dissertation entitled " Functional Heterogeneity of Striatopallidal Subregions" has since been published in several research articles. Here are a few of the references for this work:
We examined rodent fixed action patterns used for primary responses to unconditioned stimuli (natural rewarding stimuli) and during complex action sequences during grooming. Here are examples of the rodent behavior we examined in detail and used to delineate striatal subregions involved in particular higher motor functions:
Aversive taste reactions such as paw treading and fixed action patterns embedded within grooming bouts. Striatal lesions to ventral pallidal areas led to enhanced aversive taste reactions to palatable stimuli while lesions to the anterior dorsolateral striatal selectively decreased grooming chain completion. Please read the articles below for more information:
Where does damage lead to enhanced food aversion: the ventral pallidum/substantia innominata or lateral hypothalamus Cromwell HC, Berridge KC. Brain Res. 1993 Oct 8;624(1-2):1-10. Erratum in: Brain Res 1994 Apr 11;642(1-2):355.
Mapping of globus pallidus and ventral pallidum lesions that produce hyperkinetic treading. Cromwell HC, Berridge KC. Brain Res. 1994 Dec 30;668(1-2):16-29.
Motivational-sensorimotor interaction controls aphagia and exaggerated treading after striatopallidal lesions. Berridge KC, Cromwell HC. Behav Neurosci. 1990 Oct;104(5):778-95.
Implementation of action sequences by a neostriatal site: a lesion mapping study of grooming syntax. Cromwell HC, Berridge KC. J Neurosci. 1996 May 15;16(10):3444-58.
The traineeship focused on neurophysiology and basal ganglia function. I worked in Nat Buchwald/Micheal Levine laboratory at the Mental Retardation Research Center. This group completed the initial functional electrophysiological recordings of basal ganglia neurons and published widely on the neurophysiology of this system. My work included current clamp recordings of basal ganglia neurons investigating effects of cortical lesions and examining the interactions of neurotransmitter systems on the medium spiny cell synaptic responses.
Neocortical damage alters synaptic responses of neostriatal neurons in vitro.Cromwell HC, Levine MS. Neuroscience. 1996 Nov;75(2):361-72.
Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice.Levine MS, Altemus KL, Cepeda C, Cromwell HC, Crawford C, Ariano MA, Drago J, Sibley DR, Westphal H. J Neurosci. 1996 Sep 15;16(18):5870-82.
Decortication decreases paired-pulse facilitation in the neostriatal slice of the rat.Cromwell HC, Buchwald NA, Levine MS. Neurosci Lett. 1995 Jun 16;192(3):213-7.
Relative reward processing in primate striatum. Cromwell HC, Hassani OK, Schultz W. Exp Brain Res. 2005 May;162(4):520-5. Epub 2005 Mar 8.
Effects of expectations for different reward magnitudes on neuronal activity in primate striatum. Cromwell HC, Schultz W. J Neurophysiol. 2003 May;89(5):2823-38. Epub 2003 Jan 29.
Influence of expectation of different rewards on behavior-related neuronal activity in the striatum. Hassani OK, Cromwell HC, Schultz W. J Neurophysiol. 2001 Jun;85(6):2477-89.
Teeda Cromwell is a great traveler!
Wood County Fair is always a big hit!
Angsane enjoyed being shaken by the Kamikaze ride!
Samuel and Angsane are impressed by the Wood County USA tractors.