If you attempt to execute a Visual Basic or C# program in Debug mode, you might see the following error message: Unable to debug. The binding handle is invalid. This condition is likely in University computer labs and is possible on other computers. This is a known problem and can be fixed by following these steps.

Choose the last item in the Project menu (Properties) and click on Debug in the left margin. You will see the following:

Remove the checkbox from the last item (Enable the Visual Studio hosting process) and close the Properties window. Your project should now execute without error.

Note that you will need to repeat this step for any future projects that have this problem.