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 Professor and Ohio Eminent Scholar
Office: 021 Overman Hall
Phone: (419) 372-1840
Email: hplu@bgsu.edu
Personal site: Visit
Biographical Facts
Joined the faculty in 2006
Ph.D., Columbia University (1991)
M.S., Peking University, P.R. China (1984)
Research Interests
Our research is focused on the use of single molecule techniques to
understand molecular dynamic processes and the effects of the local
environment on these processes. We have been developing and applying
time-resolved, nanoscale site-specific, single molecule methods that are
an effective alternative to conventional methods, providing information
under conditions most applicable to the natural processes underlying the
area of research interest. Single-molecule approaches are useful and
unique in studying heterogeneous and complex systems because the
inhomogeneity can be identified and/or removed by studying one molecule
at a time. Single molecules and molecular complexes can be observed as
they traverse a wide range of energy states in real-time and the effect
of this ever changing "system configuration" on chemical/biological
reactions and other dynamical processes can be mapped.
Our current research work has been focused on (1) conformational
dynamics and reaction in proteins and protein complexes under
physiological conditions, and our long-term goal is to study
single-molecule protein conformational dynamics and reactions in living
cells; and (2) inhomogeneous interfacial chemical and biological
reaction dynamics in solar energy conversion, bioremediation, and
environmental systems, focusing on fundamental understanding of the
controlling physical and chemical properties, such as, Franck-Condon
coupling and barrier, vibrational and solvent relaxation energetics,
molecular distributions, redox states identification, and molecular
motions.
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