Session I - Functional Genomics
     
    Overview - Xiche Hu (University of Toledo)

    Introduction of PIs

    Discussion and comments noted by the Session Chair

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    PI's

    Bill Scovell (BGSU): Transcriptional regulation; HMG-1 and TATA Binding Protein

    Bob Trumbly (MCO):  Transcription in yeast; corepressors.  Functional homologs in humans and their roles in development

    Darren Sledjeski (MCO):  Role of RNAs in regulating prokaryotic gene expression; proteins involved in pathogenesis

    Mike Boyle (MCO):  Molecular pathogenesis, immunoglobulin-binding proteins

    Wes Sampson (UT):  Management of Prot. Exp. Initiative; data mining tools

    Steve Pecsenye (Consultant):  Informatics, representation of data; promethean informatics

    Neocles Leontis (BGSU):  RNA structure and function; modeling

    Garry Cole (MCO):  Protein Microarrays; post-translational modification; antibody arrays

    Carol Heckman (BGSU):  Signal Transduction; Protein Kinase C isoforms

    Keith Schlender (MCO):  Protein Kinases and signal transduction

    Cynthia Smas (MCO):  Obesity research; adipose tissue development; microarray technology

    Han-Fei Ding (MCO):  Cancer treatment with DNA-damaging drugs; why chemo/radiation treatments fail; apoptosis - screening for factors that affect apoptosis

    Jim Wilkey (UT):  Center for Drug Design; drug target identification

    Tim Muesser (UT):  X-ray crystallography; DNA replication; high-throughput protein crystal screening; DNA structure recognition proteins

    Gloria Borgstahl (UT):  Protein crystallography; X-ray diffraction ? underused facilities!  DNA repair and recombination

    George Cicila (MCO):  Genes responsible for quantitative traits; hypertension in rat model system; strains divergent in specific traits; resolution of genetics ? 10 centimorgans = 20 megabasepairs

    Ron Viola (UT):  Crystallography; support equipment and facilities are available

    John Gray (UT):  Plant molecular biology

    Mary Wilmes-Riesenberg (BGSU):  Salmonella pathogenesis

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    Discussion and comments noted by the Session Chair

    Comments: Strengths noted in Signal Transduction and Drug Design and target identification

    Discussion: 
     

    • We need a resource catalog of people and their expertise
    • We need to utilize under-utilized resources
    • We must seize the opportunity to integrate Bioinformatics NOW!


     Uniqueness builds opportunities for grants:
     

    • Protein structure/purification/proteomics
    • Integrating Biological Science in a larger sense 

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March 2001 / dmartin@bgnet.bgsu.edu / Disclaimer