Table 10: Isostericity Matrix for cis Hoogsteen/Sugar Edge geometry. Both A•A and U•G have been observed crystallographically. (I) indicates pairs inferred from covariations observed in the 1089/1090 side-by-side pair in the 23S rRNA L11 binding site. (I*) indicate covariations only observed for mitochondrial sequences.

Sugar Edge

Hoogsteen

A

C

G

U

A

I1

I1

I1

I1

C

I1

I1

I1

I1

G

(I1)

X

I1

X

U

I2

(I1)

I1

I1