RON C. WOODRUFF (e-mail: rwoodru@bgnet.bgsu.edu)
Ph.D., Utah State
Research Interests: I am involved in experimental and theoretical evolutionary genetics,
including the role of mutagens in evolution and aging, and the role of transposable DNA elements in
mutagenesis and molecular evolution. Examples of our research are given in the articles below.
Joint Editor-in-Chief, GENETICA
Editorial Board, Journal of Heredity
Selected Publications:
Azad, P. and R. C. Woodruff. 2006. Mutation and cloning efficiency. Cloning and Stem Cells. 8: 237-239. Abstract
Gong, Yi, J. N. Thompson, jr. and R. C. Woodruff. 2006. Effect of deleterious mutations on lifespan in Drosophila melanogaster. Journal of Gerontology: Biological Sciences 61A: 1246-1252.Abstract
Gong, Yi, Sheng Gu and R. C. Woodruff. 2005. The influence of premeiotic clusters of mutation on indirect estimations of mutation rate. Human Heredity 60:150-155. Abstract
Woodruff, R.C. and J.N. Thompson, Jr. 2005. The fundamental theorem of neutral evolution: Rates of substitution and mutation should factor in premeiotic clusters. Genetica 125:333-339. Abstract
Gong, Yi, J.N. Thompson, Jr. and R.C. Woodruff. 2005. Deleterious genomic mutation rate for viability in Drosophila melanogaster using concomitant sibling controls. Biology Letters 1:492-595 Abstract
Woodruff, R.C., J.N. Thompson, Jr. and S. Gu. 2004. Premeiotic clusters of mutation and the cost of natural selection. Journal of Heredity 95:277-283. Abstract Medline
Woodruff, R.C., J.P. Phillips and A.J. Hilliker. 2004. Increased spontaneous DNA damage in Cu/Zn superoxide dismutase (SOD1) deficient Drosophila. Genome 47:1029-1035. Abstract Medline
Symphorien S.and R.C.Woodruff. 2003. Effect of DNA repair on aging of trangenic Drosophila melanogater:mei-41 Locus. J. of Gerontology: Biological Sciences 58A:782-787. Abstract Medline
Woodruff, R.C. and J.N. Thompson, Jr. 2003. The role of somatic and germline mutations in aging and a mutation interaction model of aging.Journal of Anti-Aging Medicine 6:29-39 Abstract Medline
Woodruff, R.C. and J.N. Thompson, jr. 2002. Mutation and premating isolation. Genetica, 116:371-382. Abstract Medline
Haller, B.S. and R.C. Woodruff. 2000. Varied expression of a Y-linked P[w
Itoh, M., R.C. Woodruff, M.A. Leone and I.A. Boussy. 1999. Genomic P elements and P-M characteristics of eastern Australian populations of Drosophila melanogaster. Genetica, 106: 231-245. Abstract Medline
Woodruff, R.C., and J.N. Thompson, jr. J.S.F. Barker and H. Huai. 1999. Transposable DNA elements in somatic cells reduces fitness, mating activity, and locomotion of Drosophila melanogaster, Genetica, 107: 261-269. Abstract Medline
Russell, A.L. and R.C. Woodruff. 1999. The genetics and evolution of the mariner, transposable element in Drosophila simulans: worldwide distribution and experimental population dynamics. Genetica, 105:149-164. Abstract Medline
Thompson, J.N., jr., R.C. Woodruff and H. Huai. 1998 Mutation rate: A simple concept has become complex, Environmental and Molecular Mutagenesis, 32:292-300. Abstract Medline
Boussy, I.A., M. Itoh, D. Rand and R.C. Woodruff. 1998. Origin and decay of the P element-associated latitudinal cline in Australian Drosophila melanogaster. Genetica. 140:45-57.Abstract Medline
Thompson, J.N., Jr. and R.C. Woodruff. 1999. Mutation and Mutagenesis: Overview. In: Encyclopedia of Genetics: Basics and Applications. Ed. J. Knight. Salem Press, Pasadena CA. 418-425.
Woodruff, R.C. and J.N. Thompson, Jr., Eds. 1998. Mutation and Evolution. In: Contemporary Issues in Genetics and Evolution. Kluwer Academic PUblishers, Dordrecth, The Netherlands.
Arking, R. and R.C. Woodruff. 1998. Using Drosophila in experimental aging research. In Methods in Aging Research, Ed. B.P. Yu, CRC Press. pp 145-165.
Huai, H. and R.C. Woodruff. 1998. Clusters of new identical mutants and
the fate of underdominant mutations. Genetica. 102/103:489-505.
Abstract Medline
Huai, H. and R.C. Woodruff. 1998. With the correct concept of mutation rate, cluster mutations can explain the overdispersed molecular clock. Genetics 149:467-469
Huai, H. and R.C. Wooddruff. 1997. Clusters of identical new mutations can account for the "overdispersed" molecular clock. Genetics 147:339-348.Abstract Medline
Woodruff, R.C., H. Huai and J.N. Thompson, Jr. 1996. Clusters of new mutations in the evolutionary landscape. Genetica 98:149-160.Abstract Medline
Merker, R.J. and R.C. Woodruff. 1996. Molecular evidence for discrete breeding stocks of walleye (Stizostedion vitreum) in western Lake Erie. J. Great Lakes Research 22(2):280-288.
Woodruff, R.C. and A.G. Nikitin. 1995. P DNA element movement in somatic cells reduces lifespan in Drosophila melanogaster. Evidence in support of the somatic mutation theory of aging. Mutation Research 338:35-42.Abstract Medline
Nikitin, A.G. and R.C. Woodruff. 1995. Somatic movement of the mariner transposable element and lifespan of Drosophila species. Mutation Research 338:43-49.Abstract Medline
Szekely, A.A., R.C. Woodruff and R. Mahendran. 1994. P element-mediated germ line transformation of Drosophila melanogaster with TC1 transposable DNA element from Caenorhabditis elegans. Genome 37:356-366.Abstract Medline
Woodruff, R.C. 1992. Transposable DNA elements and life history traits. I. Transpositions of P DNA elements in somatic cells reduces the lifespan of Drosophila melanogaster. Genetica 86:143-154.Abstract Medline
Woodruff, R.C. and J.N. Thompson, Jr. 1992.. Have premeiotic clusters of mutation been overlooked in evolutionary theory? Journal Evolutionary Biology 5:457-464.
Jakubczak, J.L., M.K. Zenni, R.C. Woodruff and T.H. Eickbush. 1992. Turnover of R1 (TypeI) and R2 (TypeII) retrotransposable elements in the ribosomal DNA of Drosophila melanogaster. Genetics 131:129-142Abstract Medline
Woodruff, R.C. and M.A. Seeger. 1991. Test of a semiselective screen for induced aneuploidy in germ cells of Drosophila melanogaster females with structurally normal chromosomes. Mutation Research 252:61-82.Abstract Medline
Woodruff, R.C., J.N. Thompson, Jr., H.N.B. Gopalan, W.A. Ngure, E.S. Norris and A.A. Szekely. 1990. Genetic and molecular analyses of P DNA elements sampled from natural populations Drosophila melanogaster in Kenya. Molecular Evolution, UCLA Symposia on Molecular and Cellular Biology, New Series, Volume 122, p. 117-125.