Ph. D., Northwestern University

   

Office:     455B Life Sciences Building

Phone:   1-419-372-8259

Email:     stanlee@bgsu.edu

   

Research:

Insect endocrinology and biochemistry

   

 

   

Research Interests:

Biochemistry and endocrinology of insect development and reproduction with particular emphasis on ecdysteroids (biosynthesis, titer regulation, physiology, natural products chemistry), cytochrome P-450 systems, and effects of plant allelo chemicals.

Selected Publications:

Mitchell, M.J., J.R. Crooks, D.P. Keogh and S.L. Smith. 1999. Ecdysone 20-monooxygenase activity during larval-pupal-adult development of Manduca sexta. Arch. Insect Biochem. Physiol. 41:24-32.

Mitchell, M.J., S.L. Smith, S. Johnson and E.D. Morgan. 1997. Effects of the neem tree compounds azadirachtin, 6-desacetylnimbin, nimbin and salamin on ecdysone 20-monooxygenase activity. Arch. Insect Biochem. Physiol. 35:199-209.

Mitchell, M.J., D.P. Keogh, J.R. Crooks and S.L. Smith. 1993. Effects of plant flavonoids and other allelochemicals on insect cytochrome P-450 dependent steroid hydroxylase activity. Insect Biochem. Molec. Biol. 23:65-71.

Keogh, D.P., M.J. Mitchell, J.R. Crooks and S.L. Smith. 1992. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Experientia 48:39-41.

Keogh, D.P., and S.L. Smith. 1991. Regulation of cytochrome P-450 dependent steroid hydroxylase activity in Manduca sexta: effects of the ecdysone agonist RH5849 on ecdysone 20-monooxygenase activity. Biochem. Biophys. Res. Comm. 176:522-527.

Keogh, D.P., R.F. Johnson and S.L. Smith. 1989. Regulation of cytochrome P-450 dependent steroid hydroxylase activity in Manduca sexta: evidence for the involvement of a neuroendocrine-endocrine axis during larval-pupal development. Biochem. Biophys. Res. Comm. 165:442-448.

Mitchell, M.J., and S.L. Smith. 1988. Effects of the chitin synthetase inhibitor plumbagin and its 2-demethyl derivative juglone on insect ecdysone 20-monooxygenase activity. Experientia 44:990-991.

Mitchell, M.J., and S.L. Smith. 1988. Ecdysone 20-monooxygenase activity throughout the life cycle of Drosophila melanogaster. Gen Comp. Endocrinol. 72:467-470.

Smith, S.L., and M.J. Mitchell. 1988. Effects of azadirachtin on insect cytochrome P-450 dependent ecdysone 20-monooxygenase activity. Biochem. Biophys. Res. Comm. 154:559-563.