Ph. D., University of Arkansas

   

Office:     504C Life Sciences Building

Phone:   1-419-372-8724

Email:     rjamasb@bgsu.edu

   

Research:

Cancer immunology, microbiology

   

   

Research Interests:

Cancer immunology, microbiology: The research interest of this investigator has been focused on the biological and immunological characterization of cancer cells. In the course of these studies both in vivo and in vitro tumor lines have been established and studied in detail. Currently, however, emphasis has been placed on the role of tumor heterogeneity on the process of tumor progression, metastasis and radiation sensitivity. Cytogenetic abnormalities of these lines are also being investigated.

Monoclonal antibodies (MAbs) directed against tumor associated antigens in experimental animal models have been produced and characterized. More recently, MAbs to human tumor systems have also been produced and characterized. Development of monoclonal antibodies to clinically significant microorganisms is another branch of the research interest in our program.

Selected Publications:

Jamasbi, R.J., K. t. Blakely and M.E. Geusz. 2008. Bioluminescence imaging of host responses to tumor cells implanted into syngeneic mice. AACR 49: 4356.

Hiler, D. K. Blakely, R.J. Jamasbi and M. Geusz. 2008. Mapping the mouse physiome through whole animal bioluminescence imaging. OCC Bio 12:32.

Jamasbi, R.J., E.M. Proudfoot. 2008. Phenotypic and genotypic characteristics of P. aeruginosa clinical isolates: rate of occurrences of different serotypes antimicrobial susceptibility profiles and molecular typing. Lab Medicine 39: 155-161.

Jamasbi, R.J., and E.M. Proudfoot. 2007. Determination of genotypic profiles of clinical isolates of P. aeruginosa. ASM 107.

Jamasbi, R.J., A.R. Chakraborty, S.J. Kennel. 2006. Differential expression of α₃β₁ and α₆β₄ integrin molecules on different rat and human esophageal cell lines. AARC 47: 526

Jamasbi, R.J., S.J. Kennel, T. Langford and L.J. Foote. 2005. α₃β₁ integrin constitute a major antigenic determinant on a subset of human esophageal cancer cell lines. AACR 46: 1211-1212.

Baird, M., S. K. Kulp, S.C. Chen, D.G. Beer, R.J. Jamasbi and L.A. Kersty. 2005. A novel histone deacetylase inhibitor, HDAC-42 induces apoptosis, inhibits proliferation and arrests growth of esophageal cancer cells. AACR 46: 423.

Jamasbi, R.J., S.J. Kennel, L.C. Waters, L.J. Fode and M.J. Ramsey. 2004. Genetic analysis of Pseudomonas aeruginosa by enterobacterial repetitive intergenic consensus polymeraes chain reaction (PCR) and arbitrary-primed PCR: Gel analysis compared with microchip gel electrophoresis. J. of Infection Control and Hospital Epidemiology 25:65-71.

Jamasbi, R.J., G.D. Stoner, L.J. Foot, S.J. Kennel. 2003. A monoclonal antibody to a carbohydrate epitope expressed on glycolipid and on α331 intogrin on human esophageal carcinoma. Hybridoma and Hybridomomics 22: 367-376.

Jamasbi, R.J. 1999. Frequency of infections caused by serotype 03, 06, and 011 of Pseudomonas aeruginosa in three northwestern Ohio hospitals as determined by ELISA using specific monoclonal antibodies. Ohio J. Sci. 99:10-15.

Khare, L., C.L.K. Sabourn, R.J. Jamasbi and G.D. Stoner. 1999. Altered location of E-codhrir and ?-catenin in rat esophageal tumors. Int. J. Oncology 14: 33-40

Heckman, C.A., R.J. Jamasbi, and E. Peña. 1999. Describing shape dynamics in transformed cells through latent factors. Exp. Cell Res. 246-269.

Jamasbi, R.J., M-Q. Ye and T.M. Norvell. 1997. Cytogenetic analyses of a murine carcinoma cell line and six metastatic derivatives with different degrees of radioresistability. In Vitro Cellular and Developmental Biology. 33: 133-144.

Wang, D., J. Sneddon, S-J Cheng, R.J. Jamasbi and G.D. Stoner. 1995. Frame-shift mutation in codon 176 and the P53 gene in rat esophageal epithelial cells transformed by benzo(a)pyrene-dihydrodial. Molecular Carcinogenesis 14: 84-93.

Cosma, G.W., F. Hubbard, R.J. Jamasbi and S.J. Garte. 1994. Selection for rat tracheal epithelial cells containing an activated ras oncogene during progression. J. Cancer Res. and Clinical Oncology 120: 641-644.

Jamasbi, R.J., X. Wan and G.D. Stoner. 1994. Epitope masking of rat esophageal carcinoma tumor-associated antigen by certain coexisting glycolipid and phospholipid molecules: a potential mechanism for tumor cell escape from the host immune responses. Cancer Immunol. Immunother 38: 99-106.

Jamasbi, R.J. 1994. Generation of immunoprotection against equamous cell carcinomas by in vitro cultivation and a possible mechanism of action. Ohio J. Sci. 94: 14-23.

Wan, X., R.J. Jamasbi and G.D. Stoner. 1993. Characterization of a monoclonal antibody reactive with a glycolipid antigen expressed by tumorigenic and certain immortalized, non-tumorigenic rat esophageal epithelial cell lines. Cancer Immunol. Immunother. 36: 94-100.

Jamasbi, R.J., S.J., Kennel and G.D. Stoner. 1992. A monoclonal antibody produced against a rat esophageal carcinoma cell line reacts with an integrin-like molecule expressed by rat epithelial cells. Hybridoma. J. of Cell. and Molec. Biol. 11: 581-594.

Jamasbi, R.J., and E.H. Perkins. 1990. Biological heterogeneity and radiation sensitivity of in vitro propagated lung metastatic lines originated from a transplantable squamous cell carcinoma of BALB/c mouse, in vitro. Cell Dev. Biol. 26: 222-228.