Ph. D., Michigan State University

   

Email:     dbeck@bgsu.edu

   

Research:

Mutagenesis and DNA repair; microbiology

   

Beck Lab Home Page

   

Research Interests:

Research in our lab focuses on the biological effects of damage caused in DNA by the antitumor agents cisplatin and carboplatin. Comparative studies of the genotoxic properties of active and inactive antitumor platinum compounds are carried out. Ongoing research will characterize repair of damage in DNA and the mutagenic effects of single cisplatin adducts inserted in plasmid DNA at selected sites in target genes for mutagenesis. Information will be obtained on compounds important for their chemotherapeutic activity and mechanisms of cellular resistance to platinum anticancer agents (analogous to tumor resistance in cancer patients).

Selected Publications:

Keller, K.L., T.L. Overbeck-Carrick, and D.J. Beck. 2001. Survival and induction of SOS in Escherichia coli treated with cisplatin, UV-irradiation, or mitomycin C are dependent on the function of the RecBC and RecFOR pathways of homologous recombination, Mutat. Res. 486: 21-29.

Overbeck, T.L., J. Knight and D.J. Beck. 1996. A comparison of the genotoxic effects of carboplatin and cisplatin in Escherichia coli. Mutat. Res. 362:249-259.

Beck, D.J., and S. Popoff. 1994. Toxic effects of cis- and trans-diamminodichloroplatin(II) in uvrD mutants of Escherichia coli. Ohio J. Sci. 94(4):99-104.

Popoff, S., and D.J. Beck. 1987. Repair of plasmid DNA damaged in vitro with cis- or trans-diamminedichloroplatinum(II) in Escherichia coli. Mutat. Res. 183:129-137.

Beck, D.J., S. Popoff, A. Sancar and W.D. Rupp. 1985. Reactions of the UVRABC excision nuclease with DNA damaged by diamminedichloroplatinum(II). Nuc. Acids Res. 13:7395-7412.