Arthur S. Brecher
Arthur S. Brecher, Ph.D.
Arthur S. Brecher, Ph.D.Professor
210 Physical Sciences Laboratory Building
419.372.2044
artbrec@bgsu.edu
Biographical Facts:
Joined the faculty in 1969
Ph.D., U.C.L.A. (1956)
B.S., City College of New York (1948)
Research Interests:
Currently, we are studying the blood
coagulation cascade and are examining the effect of acetaldehyde upon
the coagulation components. This relates directly to the effect of
alcohol metabolites upon the enzymes, zymogens, protease inhibitors
and glycosaminoglycans, such as heparin. Additionally, we are
chemically modifying heparin and studying the anticoagulant effects of
its analogs. Finally, the effect of acetaldehyde on hypertension,
hypotension, pancreatitis, and emphysema are being explored.
In separate studies, we are quantitating the effect of
protamine sulfate and other small peptides with hormonal potential on
the interaction of blood coagulation factors with antithrombin III.
Selected Publications:
A.S. Brecher, S.J. Murrey, K.D. Gray, and J.N.
Poulimenos. Anticoagulant effect of captopril. J. Cardiovascular
Pharmacol., 2007, In Press.
A.S. Brecher and R. Dubord. Captopril and Lisinopril decrease
acetaldehyde effects upon prothrombin time. Digestive Diseases &
Sciences, 2007, In Press.
A.S. Brecher and R. Dubord. Effect of acetaldehyde upon
cathepsin G and chymase. NRAS implications. Digestive Diseases &
Sciences, 2007, In Press.
E.A. Suchocki and A.S. Brecher. The effect of acetaldehyde on
human plasma factor XIII function. Dig. Dis. Sci. 2007, Apr. 10 (Epub
ahead of print).
A.S. Brecher, A.R. Moon, and K.D. Gray. The effect of
acetaldehyde-glycosaminoglycan mixtures upon Factor IXa and Factor
IX-Deficient Plasma. ALCOHOL, (2006) 39, 97-104.
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Updated: 04/04/2019 11:02AM